Molecular tweezers for lysine and arginine – powerful inhibitors of pathologic protein aggregation
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چکیده
منابع مشابه
Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation.
Molecular tweezers represent the first class of artificial receptor molecules that have made the way from a supramolecular host to a drug candidate with promising results in animal tests. Due to their unique structure, only lysine and arginine are well complexed with exquisite selectivity by a threading mechanism, which unites electrostatic, hydrophobic and dispersive attraction. However, tweez...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2016
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c6cc04640a